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Bioinformatics Engineer

Department: R&D-Computation
Location: Seattle, WA

POSITION: Bioinformatics Engineer

REPORTS TO: Director of Computational Biology

DEPARTMENT: Computational Biology

STATUS: Exempt



We are seeking a qualified individual for the position of Bioinformatics Engineer. As a Bioinformatics Engineer, you will work within a team of bioinformatics scientists and software engineers to play a pivotal role in solving important problems in cancer detection & monitoring through genomics tool & pipeline development & deployment.

As a part of the Computational Biology Department you will work on projects of novel method development in NGS data analysis, tool/pipeline development, process automation, and deploying distributed high-throughput genomics pipelines on cloud environments. Most of your work will focus on taking our Duplex Sequencing technology to higher levels of accuracy, accessibility, efficiency and utility across many scientific fields including early disease detection, disease monitoring, mixture deconvolution, and forensics. A process-oriented individual with exceptional attention to detail will excel in the role of Bioinformatics Engineer. Familiarity with agile programming methods such as test-driven development, collaborative programming, version control flow, and code quality standards is ideal, however, we are eager to support efforts to round out any skills that have not been previously acquired! At TwinStrand, you will learn many skills beyond those required for the core role of Bioinformatics Engineer as our team is incredibly education and career development focused.

You are the ideal Bioinformatics Engineer if you love working within a high-performance team, in a collaborative environment, to deliver high-quality solutions of bioinformatics processing. We need your expertise in bringing our Duplex Sequencing technology to more researchers and clinicians so we can continue to pioneer solutions for human health improvement through scientific discovery.


  • Develop and deploy accurate, maintainable, and well-architected core R&D and production software for high-throughput NGS data processing (tools and pipelines) in cloud environments
  • Define requirements for new computational methods and software based on the needs of our internal R&D group, external customers, and independent research partners
  • Work collaboratively within a development team to continuously improve our existing methods and processes as well as invent and discover new ways to analyze and produce novel scientific results from Duplex Sequencing datasets
  • Conduct system level testing, automation tests, and other methods to continuously improve our production and research software
  • Architect and engineer processes that relate to bioinformatics data processing, laboratory information management, and large-scale dataset curation and analysis


  • B.S. in computer science, engineering, or related field. 3-5+ years of experience
  • Ability to work well within a team, in a fast-paced environment
  • Expert ability in at least one programming language, and proficiency in others
  • Experience in developing genomics pipelines and containerizing workflows
  • Familiarity with high-throughput sequencing libraries and short-read sequencing
  • Familiarity with common bioinformatics file formats such as BAM/SAM and VCF
  • High competency with cloud development and deployment
  • High competency with version control systems like Git
  • Effective communication skills.


  • Have an M.Sc. or Ph.D. in computer science, engineering, or related field
  • Have experience with Amazon Web Services like Batch, EC2, and S3
  • Have experience with DevOps, analytics, and big data systems
  • Have previous biotechnology experience, startup company a bonus



  • Prolonged periods sitting at a desk and working on a computer.
  • Must be able to lift up to 15 pounds at times and maintain a home office.
  • Ability to travel nationally up to 10% of time for conferences and headquarters visits.



  • A mission to be proud of. You will help to provide access to a technology with unprecedented sensitivity that makes it possible to solve previously unsolvable scientific problems in basic research and translational medicine, with direct and immediate benefits to human health
  • Competitive compensation plan
  • Comprehensive benefits: medical, dental and vision benefits for employees and dependents, sponsored life, short and long-term disability insurance, and 401(k) retirement savings plan
  • Fun and high-performing work environment
  • Remote work options available now, and in the future
  • Beautiful new waterfront facility overlooking Puget Sound, located in downtown Seattle
  • Subsidized transportation program: parking, bus, ferry, rideshare and more
  • Onsite gym, showers, bike storage
  • Social events, weekly happy hours, well-stocked kitchen



We are a vibrant, young company committed to applying a powerful new genomic technology across disciplines to improve human health and accelerate scientific discovery. Our mission is to develop and deliver the unprecedented accuracy of Duplex Sequencing™ for applications in the life sciences and medicine where it can do the greatest good for the maximum number of people.

Our business is multifaceted and encompasses internal development projects, external collaborations, and empowering of our partner organizations and customers. Our mission is strongly rooted in academic principles of responsible citizenship within the broader scientific community, yet executed with the nimbleness of a startup, such that research can be rapidly translated into solutions that benefit the scientific and medical community. To the greatest extent possible, we strive for open sharing of knowledge and discovery through academic presentations and peer-reviewed publications.

At TwinStrand we put a premium on creativity, dynamic thinking and a rigorous scientific approach. You will be challenged to push the boundaries of your knowledge, skills and comfort zone and to take ownership of your area of expertise. We expect all team members to take on some form of leadership role over time and mentor new team members as we continue to expand. We want every member of our community to come to work excited each day and able to take pride in the high-quality science to improve human health that they are contributing to.

TwinStrand Biosciences is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

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